Curtis received 64 votes on the presidential ballot at the 1928 Republican National Convention in Kansas City, out of 1,084 total. The winning candidate, Herbert Hoover, secured 837 votes, having been the favourite for the nomination since August 1927 (when President Calvin Coolidge ruled himself out of contention). Curtis was a leader of the anti-Hoover movement, forming an alliance with two of his Senate colleagues, Guy Goff and James E. Watson, as well as Governor Frank Lowden of Illinois. Less than a week before the convention, he described Hoover as a man "for whom the party will be on the defensive from the day the is named until he close of the polls on election day". However, despite his opposition, Curtis had no qualms about accepting the vice-presidential nomination.