Lloyd-Hughes was born in 1988 in London, the son of Lucy Appleby and Timothy Lloyd-Hughes. He has an older brother, actor Henry Lloyd-Hughes. They both acted in Miliband of Brothers. In 2011 he finished his acting training at the Guildhall School of Music and Drama in London. Fred Macpherson, lead singer of the band Spector, and formerly of Les Incompétents and Ox.Eagle.Lion.Man, is his cousin.