After defending his doctoral thesis on the study of singular points of the system of differential equations, Poincaré wrote a series of memoirs under the title "On curves defined by differential equations" (1881–1882). In these articles, he built a new branch of mathematics, called "qualitative theory of differential equations". Poincaré showed that even if the differential equation can not be solved in terms of known functions, yet from the very form of the equation, a wealth of information about the properties and behavior of the solutions can be found. In particular, Poincaré investigated the nature of the trajectories of the integral curves in the plane, gave a classification of singular points (saddle, focus, center, node), introduced the concept of a limit cycle and the loop index, and showed that the number of limit cycles is always finite, except for some special cases. Poincaré also developed a general theory of integral invariants and solutions of the variational equations. For the finite-difference equations, he created a new direction – the asymptotic analysis of the solutions. He applied all these achievements to study practical problems of mathematical physics and celestial mechanics, and the methods used were the basis of its topological works.