Vinson's screen career often featured her in roles in which she played the part of the other woman or (pre-Code) loose women with active romantic lives. Her first film role was Jewel Robbery (1932), which starred william Powell and Kay Francis. She appeared as Doris Delafield in The Kennel Murder Case, which starred Powell as Philo Vance. One of her memorable roles was in The Wedding Night (1935). She played the wife of Gary Cooper and the rival of Anna Sten, in a story about the Connecticut tobacco fields. Another performance was in the RKO film In Name Only (1939), in which she was cast as the treacherous friend of Carole Lombard, Kay Francis and Cary Grant. Another stand-out role for Vinson was as an undercover federal agent posing as a femme fatale opposite Richard Cromwell in Universal Pictures's anti-Nazi action drama entitled, Enemy Agent (1940). She followed that role with the role of Helen Draque in The Thin Man Goes Home. Vinson's film career ended in 1945.