Ware appeared in the films Cop Out (2010) and Shame (2011). From 2011 to 2012, she played Emma Kane, the estranged addict daughter of Chicago mayor Tom Kane, in the Starz series Boss. In 2013, she was cast in ABC drama series Betrayal as lead character, and she appeared in Spike Lee's thriller film Oldboy. In 2015, Ware played the female lead, opposite Rupert Friend, in the action film Hitman: Agent 47.