Baldwin first voiced Aku (from Samurai Jack) in the 2009 video game Cartoon Network Universe: FusionFall. He also voiced Frank Fontaine, the main antagonist in BioShock; though Karl Hanover, who voiced Fontaine's alter ego Atlas in the first game, replaced Baldwin as Fontaine in BioShock 2 and BioShock Infinite: Burial at Sea. His voice can also be heard in numerous other video games, including Tom Clancy's Rainbow Six: Lockdown, Assassin's Creed: Brotherhood, F.E.A.R. and Fallout 4.