Canning was born into an Anglo-Irish family at his parents' home in Queen Anne Street, Marylebone, London. Canning described himself as "an Irishman born in London". His father, George Canning, Sr., of Garvagh, County Londonderry, Ireland, was a gentleman of limited means, a failed wine merchant and Lawyer, who renounced his right to inherit the family estate in exchange for payment of his substantial debts. George Sr. eventually abandoned the family and died in poverty on 11 April 1771, his son's first birthday, in London. Canning's mother, Mary Anne Costello, took work as a stage Actress, a profession not considered respectable at the time. Indeed, when in 1827 it looked as if Canning would become Prime Minister, Lord Grey remarked that "the son of an Actress is, ipso facto, disqualified from becoming Prime Minister".