Melamed's slate of upcoming films includes the Sundance film Lemon, a collaboration with Brett Gelman and Janicza Bravo, Brawl in Cell Block 99 opposite Vince Vaughn, Sean McGinly's Silver Lake, which he stars in with Martin Starr, and Dragged Across Concrete. Melamed recently starred as Sam in Lake Bell's In a World..., winner of the Waldo Salt Screenwriting Award at the Sundance Film Festival, opposite Kurt Russell and Richard Jenkins in Bone Tomahawk, and re-teamed with the Coen brothers and co-stars George Clooney, Tilda Swinton, and Ralph Fiennes in Hail, Caesar!. He starred previously in Get On Up, a bio-pic about the life of James Brown, and opposite Elliott Gould, as auteur/director Bob Wilson, in Fred Won't Move Out, a film about the decline of a stubborn patriarch and his family. Other recent films include The Dictator (2012), with Sacha Baron Cohen and Sir Ben Kingsley, where Melamed appears in a cameo as the Director of the dictator's Nuclear Weapons Program, and Some Kind of Beautiful, where Melamed plays a villain, opposite Pierce Brosnan and Jessica Alba. Melamed has also voiced cult-leader Cris Formage in the Grand Theft Auto video game series.