During the 16 years following BC 3, a number of Henenlotter feature projects came close to production, including "Sick in the Head," Henenlotter's first script collaboration with R.A. the Rugged Man, at one point scheduled to be produced under the aegis of Fangoria Magazine; but, coincidental with the general economic downturn, financing evaporated. Henenlotter has also noted the conflicts he had with producers over the film, who forced the filmmaker to walk after urging him to reedit his script so it would be "more like Saw." R.A. subsequently was able to find a new deal and very modest financing through his music industry contacts, so Bad Biology was conceived to be shot for an extremely low budget, for extremely limited, unrated theatrical play, and subsequent video release. Though only attendees at film festivals and special film events have had the opportunity to see the film (shot in traditional 35mm at Henenlotter's insistence) projected in a theater, Henenlotter claims the low budget, independent financing and the decision to forgo the ratings process allowed him a level of freedom he has been missing since his earliest films. Bad Biology was scheduled for video release in January 2010 by Media Blasters. Henenlotter appeared as himself in the documentary film Herschell Gordon Lewis – The Godfather of Gore and narrated the film on the 2010 FanTasia. In issue #304 Frank and comic Artist Joshua Emerick started the Basket Case comic strip for Fangoria. The three panel strip runs in each issue.