Pasquesi has performed at The Second City, iO Theater, Improv Institute, and Annoyance Theatre, and studied under Del Close in the early 80s and became part of the first iO Harold team "Baron's Barracudas". He appeared in four mainstage revues at Second City as well as in plays at the Steppenwolf Theatre and the Goodman Theatre. Since 2002, he has been performing with T. J. Jagodowski in "TJ and Dave".