Bucatinsky was the Writer, Producer and star of the 2001 romantic comedy All Over the Guy. He has appeared in episodes of many television series, including Curb Your Enthusiasm, Weeds, Friends, NYPD Blue, That '80s Show, Frasier, and Will & Grace, as well as an episode of Grey's Anatomy (where Bucatinsky also serves as a consulting producer). He executive produced and acted in the 2005 HBO series The Comeback along with his producing partner, Actress Lisa Kudrow. In 2008, Bucatinsky and Lisa Kudrow again worked as producers for the innovative and largely improvisational web series, Web Therapy, in which Kudrow starred and Bucatinsky also acted; Don Roos, his husband, directed.