Claudio Amendola started his movie career during the 1980s, playing comic roles in some Italian comedies directed by Carlo Vanzina. In 1987 he played his first dramatic role in Soldati - 365 all'alba, directed by Marco Risi, and in the following decade he confirmed his dramatic skills in some movies like Ultrà (1990) and The Escort (1993), both directed by Ricky Tognazzi. During the 2000s Amendola became a very popular television actor, acting in the popular fiction I Cesaroni, the Italian version of Los Serrano.