In 1995, he moved to New Zealand where he soon picked up a few acting roles. Mesure has acted, directed, designed, and written upwards of thirty productions for the Sydney University Drama Society while studying law. In 1998, he was nominated for a Best Actor New Zealand Television Award for his work as Ryan Waters on the New Zealand soap opera, City Life and in 2003 he won the Best Supporting Actor award for his work as Kees Van Damm on the New Zealand drama, Street Legal. Mesure appeared as a supporting character in Season 1 of the American TV series V, and was promoted to a regular series cast member for Season 2.