In 2007, Mendelsohn starred in the third season of the TV series Love My Way and in 2008, he appeared in Baz Luhrmann's Australia and filmed the 10-part Melbourne series Tangle, which premiered on Showcase in 2009. In 2009, he appeared in the American science fiction film Knowing directed by Alex Proyas. The same year, Mendelsohn starred as Ned in Beautiful Kate, directed by Rachel Ward, opposite Bryan Brown and Rachel Griffiths.