In addition to mafia and "tough-guy" roles, Assante has distinguished himself in historic dramas, such as Napoleon Bonaparte in 1987's Napoleon and Josephine: A Love Story opposite Jacqueline Bisset, the heroic Odysseus in The Odyssey, Friedrich Nietzsche in the film adaptation of Irving Yalom's novel When Nietzsche Wept, and as Sanchez, Queen Isabella's Minister of State, in 1492: Conquest of Paradise.