Cotton currently plays barman and factory worker Sean Tully in Coronation Street, on which he has starred since 2003. Cotton played "Alexander" in the original UK version of Queer as Folk. He has also appeared in episodes of Absolutely Fabulous as "Damon". On 13 January 2007, Cotton won the second series of ITV's Soapstar Superstar. He donated his winning money, £200,000, to the Elton John Aids Foundation. In July 2007, it was announced that Cotton would be fronting his own teatime chat show on ITV. The show, That Antony Cotton Show, was filmed with a live studio audience at Granada Television studios in Manchester, and combined Celebrity chat with topical humour. It was first broadcast on Monday 13 August 2007 however, following the end of the first series, ITV announced that the show wouldn't return for a second. He appeared on Family Fortunes on 20 September 2008 winning £10,000 for his chosen charity. In December 2008, he appeared with co-star Suranne Jones on Who Wants to Be a Millionaire?.