In 2010 he was cast as Meyer Lansky in HBO's Boardwalk Empire, first appearing in Episode 7 of Season 1, "Home" and recurring throughout the remainder of the series. In an interview with The Morton Report, Yusef described Lansky as self-educated, a massively intelligent overachiever and "a ruthless, ruthless man". Anatol's characterization of Mr. Lansky has been recognized in many publications, including author and critic Clive James's article on Martin Scorsese, as well as Michael Noble's review of the show on Den of Geek.