In 2001, Wright was cast as Laverne Roberts in the NBC comedy series, Scrubs. After six seasons, her character was killed off in "My Long Goodbye". She returned in season seven playing a new character, Nurse Shirley. Initial reports stated that her character would be the alcoholic, irreligious sister of Laverne, but these turned out to be inaccurate. She later returned to play Nurse Roberts in the season 8 finale, "My Finale", as JD is looking back on all the people in his life. In 2000s, Wright also guest starred on NYPD Blue, Cold Case, NCIS, and Mad Men. She also had supporting parts in films such as Bring It On, The Brothers, and Johnson Family Vacation.